Using with the Whole Human Brain taxonomy

ASAP-PMDBS cells were mapped to the whole human brain (WHB) taxonomy (Siletti et al., 2023), which is hierarchical taxonomy of ~3.3 million cells (neurons and non-neuronal cells) with 31 superclusters, 461 clusters, and 3,313 subclusters spanning 105 anatomical dissections across the whole human brain. The 30 ASAP-PMDBS clusters were mapped at the WHB supercluster, cluster, and subcluster levels. Click on the hyperlinks to view the ASAP-PMDBS clusters in the ABC Atlas side-by-side with the WHB neuronal and non-neuronal cells.

To change the taxonomy level filter, click on the ink drop (🌢) next to "10x Whole human brain taxonomy" and click either supercluster, cluster, or subcluster.

Using with the SEA-AD taxonomy

ASAP-PMDBS  cells were also mapped to the Seattle Alzheimer’s Disease Brain Cell Atlas (SEA-AD) taxonomy (Gabitto and Travaglini et al., 2024), which contains ~1.4 million cells from the middle temporal gyrus (MTG) clustered into 3 classes, 24 subclasses, and 139 supertypes. The 30 ASAP clusters were mapped at the SEA-AD class, subclass, and supertype levels. Click on the hyperlinks to view the ASAP-PMDBS clusters in the ABC Atlas side-by-side with the SEA-AD cells.

To change the taxonomy level filter, click on the ink drop (🌢) next to "10x Human MTG SEA-AD taxonomy" and click either class, subclass, or supertype.

Using with the SEA-AD MERFISH data

The SEA-AD taxonomy also features MERFISH spatial transcriptomic data from ~300k MTG cells from 24 of the SEA-AD donors. These cells are included in the 3 classes, 24 subclasses, and 139 supertypes. The ASAP-PMDBS cells mapped to the SEA-AD taxonomy can be viewed side-by-side with the MERFISH SEA-AD data at the class, subclass, and supertype levels. Click on the hyperlinks to view the ASAP-PMDBS clusters in the ABC Atlas side-by-side with the SEA-AD MERFISH cells.