The Cell Type Knowledge Explorer aggregates and summarizes multi-modal information about human, marmoset, and mouse cell types in the primary motor cortex. High-throughput, single-cell transcriptomic, and epigenomic profiling demonstrate broad conservation of molecular cell type identities across these three species. The Cell Type Knowledge Explorer is powered by a data-driven ontology, which drives search and connects these data to external knowledge about cell types. Each cell type has a unique Cell Type Knowledge Card, which provides summary text and visualizations of available data. These data were generated as part of the BRAIN Initiative Cell Census Network (BICCN) and described in detail in the BICCN flagship publication.
The Cell Types Knowledge Explorer will enable the neuroscience community to:
Explore features of primary motor cortex cell types including gene expression, spatial location and electrophysiological properties
Identify primary motor cortex cell types that are conserved across mammalian species
Access underlying BICCN data sets and related data exploration tools such as epigenetics browsers and tools for cell type mapping
The Cell Type Knowledge Explorer allows users to explore primary motor cortex taxonomies for the human, marmoset and mouse.
Related resources
With funding from the National Institutes of Health (NIH) and technology from Amazon Web Services (AWS), the Allen Institute is leading an effort to build the Brain Knowledge Platform (BKP) – soon to be the largest open-source database of brain cell data in the world. The BKP will host single-cell resolution neuroscience datasets from collaborative teams worldwide. It will be a premier resource to compile and standardize massive datasets on the structure and function of mammalian brains. The ultimate goal of the BKP is to enable better diagnosis and treatment of the mental and neurological disorders and diseases.
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