MapMyCells transforms cell types from a concept in publications to a tool for public research. Scientists worldwide can discover what cell types their transcriptomics and spatial data corresponds with by comparing their data to massive, high-quality reference datasets, including the Allen Institute’s whole mouse brain multi-omics atlas, which was developed as part of the NIH’s Brain Initiative Cell Census Network and is available in Allen Brain Cell Atlas.
One key advantage to MapMyCells is scale: using our cloud-based Brain Knowledge Platform and reference datasets with millions of cells, researchers can provide up to 327 million cell-gene pairs from their own data, which is a huge leap forward for working with whole-brain datasets.
MapMyCells will enable the neuroscience community to
Compare their own data to massive, high-quality, and high-resolution cell type taxonomies.
Speed up the creation of brain reference atlases by facilitating the integration of datasets from the scientific community with a shared reference.
MapMyCells offers researchers a simple two-step process to map their gene expression data against massive reference taxonomies of brain cell types. Researchers can choose from available mapping algorithms, based on their needs for speed and robustness. Outputs feature a cell identity from the reference taxonomy and corresponding confidence score for each cell in the researcher’s dataset. Learn more about MapMyCells outputs here.
Learn how to use MapMyCells with this tutorial notebook. Get a walkthrough from input file creation to initial output analysis for an example of single cell genomics in mouse.
Learn how to use MapMyCells with this tutorial notebook. Get a walkthrough from input file creation to initial output analysis for an example of single nucleus RNA-seq in human MTG.
With funding from the National Institutes of Health (NIH) and technology from Amazon Web Services (AWS), the Allen Institute is leading an effort to build the Brain Knowledge Platform (BKP) – soon to be the largest open-source database of brain cell data in the world. The BKP will host the ABC Atlas including single-cell resolution neuroscience datasets from collaborative teams worldwide. It will be a premier resource to compile and standardize massive datasets on the structure and function of mammalian brains.
The ultimate goal of the BKP is to enable better diagnosis and treatment of the mental and neurological disorders and diseases.