Seattle Alzheimer’s Disease Brain Cell Atlas
Seattle Alzheimer's Disease Brain Cell Atlas (SEA-AD) Study Documentation, Data, and Downloads
The Seattle Alzheimer's Disease Brain Cell Atlas (SEA-AD) consortium includes the Allen Institute for Brain Science, the University of Washington, and Kaiser Permanente Washington Health Research Institute and is supported by the National Institutes on Aging (NIA) grant U19AG060909.
Below you will find information and documentation about the study's data as well as links to raw and processed data.
Documentation, Data, and Downloads
Data
| File | Size | Type | Description |
|---|---|---|---|
| Donor metadata | 44 KB | .xlsx |
De-identified Donor metadata (demographic, clinical, cognitive, and neuropathological data) |
| Link to raw single nucleus data | link |
Link to Sage Bionetworks AD Knowledge Portal SEA-AD study page. Controlled access to raw 10x snRNASeq, snATACseq, and Multiome data. |
|
| Link to processed single nucleus data | link |
Link to CZI's cellxgene SEA-AD collection page. Open access to processed 10x snRNASeq data. |
|
| MRI volumetrics | 64KB | .xlsx | Post mortem MRI brain volumetrics. |
| Luminex (ABeta and Tau, MTG) | 24KB | .xlsx | Luminex data: ABeta and Tau measurements for Middle Temporal Gyrus (MTG). |
Documentation
| File | Size | Type | Description |
|---|---|---|---|
| SEA-AD cohort information | 99KB |
SEA-AD cohort selection information, inclusion/exclusion criteria |
|
| SEA-AD cohort metadata summary graphs | 514KB |
Graphs summarizing the SEA-AD cohort's age at death, sex, APOE4 status, cognitive status, CERAD score, ADNC score, Braak stage, and Thal phase. |
|
| Transcriptomics and epigenomics data generation | 95KB | Methods for 10x snRNASeq, snATACseq, and Multiome data generation and RNA Integrity Number (RIN) determination | |
| Transcriptomics: Post-sequencing data analysis | 153KB | Methods for transcriptomics data analysis. Information on development of web tools, which present transcriptomic data. | |
| Donor metadata brief descriptions | 90KB | Brief descriptions for the donor metadata elements. | |
| Donor metadata citations | 123KB |
Citations for select donor metadata elements |
|
| Consensus clinical diagnosis | 136KB | Information on clinical AD detection and consensus clinical diagnosis generation. | |
| Dissection, MRI, neuropathological analysis | 108KB | Citation for dissection, ex vivo MRI, tissue preparation, and neuropathological analysis. |
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